Fifth seed Jo-Wilfred Tsonga emerged easily from his first round matchup against Karol Beck 6-3 6-1 7-6 (7-2).
Tsonga had Beck running from corner to corner with his sharp forehand and although he dropped off a bit in the third set, he was able to prevail with help from his play around the net.
"I think I played good tennis the first two sets, and after that I lost a bit concentration at the beginning of the third set," said Tsonga.
"Then I came back, and, you know, I did some effort to come back. It was not easy today because the weather was hot. I'm happy to go through this round really quickly."
Czech sixth seed Tomas Berdych defeated the in-from David Goffin 7-5, 6-3, 6-3 while hitting 17 aces and 40 winners.
Berdych was the 2010 Wimbledon runner-up, but has never been past the round of 16 at Flushing Meadows. The 21-year-old Goffin completed just two of 18 break points.
Andy Roddick gave his home fans a little to cheers about despite knocking out another upcoming American talent in Rhyne Williams.
Roddick (30-years-old) defeated Williams (21) 6-3, 6-4, 6-4 in the youngster’s Grand Slam debut.
Second seed Agnieszka Radwanska didn’t encounter too much difficulty in her opener. Radwanska smashed Russian Nina Bratchikova 6-1, 6-1 and needed less than an hour to do so.
Radwanska reached her first Grand Slam final at Wimbledon last month, but has never advanced past her current state at Flushing Meadows- the round of 64.
Sixth seed Angelique Kerber also cruised to victory. The German was a 6-2, 6-0 winner against Britain's Anne Keothavong.
Kerber has won more WTA matches this year (54-16) than anyone else this year and has won six of her last seven.
Venus Williams’ comeback continues to progress nicely. She smashed fellow American Bethanie Mattek-Sands 6-3 6-1.